Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.74 |
| ▸ | HTR1D | P28221 | 6/20 | 0.54 |
| ▸ | HTR1B | P28222 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364891 | 0.96 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL6765275 | 0.96 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8983347 | 0.96 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| Bromide SCHEMBL7511914 | 0.94 | HTR1A (0.80) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7509146 | 0.93 | HTR1A (0.67) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| Acetic Acid SCHEMBL7513634 | 0.93 | HTR1A (0.80) | HTR1AHTR1DHTR1BDRD2 | |
| Oxalic Acid SCHEMBL7515265 | 0.93 | HTR1A (0.77) | HTR1AHTR1DHTR1BDRD2 | |
| Benzoic Acid SCHEMBL7515933 | 0.92 | HTR1A (0.64) | HTR1AHTR1DHTR1BDRD2 | |
| Iodide SCHEMBL7510396 | 0.92 | HTR1A (0.65) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| Sulfuric Acid SCHEMBL10347223 | 0.92 | HTR1A (0.75) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| US-4745126-A | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1988-05-17 | — | — | US | disclosed |