⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL751453 | 1.00 | — | — | |
| SCHEMBL3253960 | 1.00 | — | — | |
| SCHEMBL11876402 | 0.87 | TSHR (0.59) | — | |
| SCHEMBL8789838 | 0.87 | — | — | |
| SCHEMBL8487919 | 0.83 | EPHX2 (0.42) | — | |
| SCHEMBL8487922 | 0.83 | EPHX2 (0.42) | — | |
| SCHEMBL8789921 | 0.79 | — | — | |
| SCHEMBL11876487 | 0.79 | TSHR (0.56) | — | |
| SCHEMBL3389566 | 0.78 | TSHR (0.64) | — | |
| SCHEMBL28182 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 311 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10464940-B2 | Lactam kinase inhibitors | GI Therapeutics, Inc. (US) | 2019-11-05 | — | — | US | claimed |
| US-20180127431-A1 | LACTAM KINASE INHIBITORS | G1 THERAPEUTICS, INC. (US) | 2018-05-10 | — | — | US | claimed |
| US-9856268-B2 | Lactam kinase inhibitors | G1 THERAPEUTICS, INC. (US) | 2018-01-02 | — | — | US | claimed |
| EP-2953951-B1 | N2-SUBSTITUTED-N6-(6-ARYL-PYRIDINE-3-YLMETHYL)-9-CYCLOPENTYL-9H-PURINE-2,6-DIAMINE DERIVATIVES AS TUMOR SUPPRESSOR P53 ACTIVATORS FOR INHIBITING ANGIOGENESIS AND FOR TREATING CANCER | UNIV PALACKEHO (CZ) | 2017-05-03 | — | — | EP | claimed |
| EP-2831080-B1 | LACTAM KINASE INHIBITORS | TAVARES FRANCIS XAVIER (US) | 2017-03-15 | — | — | EP | claimed |
| US-20170057972-A1 | LACTAM KINASE INHIBITORS | G1 THERAPEUTICS, INC. (US) | 2017-03-02 | — | — | US | claimed |
| US-9394297-B2 | Amides as pim inhibitors | AMGEN INC. (US) | 2016-07-19 | — | — | US | claimed |
| US-9260442-B2 | Lactam kinase inhibitors | G1 THERAPEUTICS, INC. (US) | 2016-02-16 | — | — | US | claimed |
| US-20150368248-A1 | 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS | BIOPATTERNS S.R.O. (CZ) | 2015-12-24 | — | — | US | claimed |
| EP-2953951-A2 | 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS | Univerzita palackeho V Olomouci (CZ) | 2015-12-16 | — | — | EP | claimed |
| EP-0006227-B1 | ANTITHROMBOTIC PHARMACEUTICAL PREPARATION CONTAINING 2,2'-DITHIOBIS BENZAMIDE DERIVATIVES AND NEW 2,2'-DITHIOBIS BENZAMIDE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-12-27 | — | — | EP | claimed |
| US-4454128-A | ANTIBIOTICS | DR. KARL THOMAE GMBH (DE) | 1984-06-12 | — | — | US | claimed |
| EP-0021176-B1 | CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1984-01-18 | — | — | EP | claimed |
| EP-0035161-B1 | CEPHALOSPORINS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1983-11-23 | — | — | EP | claimed |
| US-4388315-A | TAUTOMERIC PYRIMIDINE DERIVATIVES | BOEHRINGER INGELEHEIM GMBH (DE) | 1983-06-14 | — | — | US | claimed |
| EP-0073454-A2 | 6-Alpha-methoxy-penicillins, their salts, process for their preparation and therapeutic agents containing these compounds | Dr. Karl Thomae GmbH (DE) | 1983-03-09 | — | — | EP | claimed |
| US-4370327-A | Cephalosporins and pharmaceutical compositions | BOEHRINGER INGELHEIM GMBH (DE) | 1983-01-25 | — | — | US | claimed |
| US-4362725-A | ANTIBIOTICS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-12-07 | — | — | US | claimed |
| EP-0016374-B1 | PENICILLINS, THEIR SALTS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1982-03-03 | — | — | EP | claimed |
| US-4289775-A | BACTERICIDAL ANTIBIOTICS | KARL THOMAE GMBH (DE) | 1981-09-15 | — | — | US | claimed |