SCHEMBL751453

SCHEMBL751453

[NH][C@H]1CC[C@H](O)CC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3253960 1.00
SCHEMBL751452 1.00
SCHEMBL11876402 0.87 TSHR (0.59)
SCHEMBL8789838 0.87
SCHEMBL8487919 0.83 EPHX2 (0.42)
SCHEMBL8487922 0.83 EPHX2 (0.42)
SCHEMBL8789921 0.79
SCHEMBL11876487 0.79 TSHR (0.56)
SCHEMBL3389566 0.78 TSHR (0.64)
SCHEMBL28182 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3294741-B1 5-SUBSTITUTED 7-[4-(2-PYRIDYL)PHENYLMETHYLAMINO]-3-ISO PROPYLPYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS USTAV EXPERIMENTALNI BOTANIKY AV CR V V I (CZ) 2019-05-01 EP claimed
US-9957273-B2 5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I. (CZ) 2018-05-01 US claimed
US-20180072736-A1 5-SUBSTITUTED 7-[4-(2-PYRIDYL)PHENYLMETHYLAMINO]-3-ISOPROPYLPYRAZOLO4,3-D]PYRIMIDINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I. (CZ) 2018-03-15 US claimed
EP-2831080-B1 LACTAM KINASE INHIBITORS TAVARES FRANCIS XAVIER (US) 2017-03-15 EP claimed
EP-2831080-A1 LACTAM KINASE INHIBITORS Tavares, Francis Xavier (US) 2015-02-04 EP claimed
WO-2013148748-A1 LACTAM KINASE INHIBITORS TAVARES FRANCIS XAVIER (US) 2013-10-03 WO claimed
JP-4743463-B2 2011-08-10 JP claimed
EP-1628968-B1 4-IMIDAZOLIN-2-ONE COMPOUNDS MITSUBISHI TANABE PHARMA CORP (JP) 2011-04-06 EP claimed
EP-1165523-B1 NEUROTROPHIC SUBSTITUTED PYRIMIDINES KRENITSKY PHARMACEUTICALS INC (US) 2007-11-07 EP claimed
US-6844347-B1 Cyclic guanosine monophosphate modulators; cardiovascular diseases; guanylate cyclase activation AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-01-18 US claimed
WO-2000061562-A1 NEUROTROPHIC SUBSTITUTED PYRIMIDINES KRENITSKY PHARMACEUTICALS INC. (US) 2000-10-19 WO claimed
WO-2000059893-A1 NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES KRENITSKY PHARMACEUTICALS INC. (US) 2000-10-12 WO claimed
US-5977102-A INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; DR. KARL THOMAE GMBH (DE) 1999-11-02 US claimed
EP-0885227-A1 PYRIMIDO 5,4-d]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION Dr. Karl Thomae GmbH (DE) 1998-12-23 EP claimed
WO-1997032882-A1 PYRIMIDO[5,4-d]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION DR. KARL THOMAE GMBH (DE) 1997-09-12 WO claimed
US-5455266-A Including an expectorant e.g bromhexine, ambroxol, dembrexine, and microbiocide in fish food; synergistic BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1995-10-03 US claimed
EP-0586738-A1 Enhanced chemotherapeutic compositions against microbial infections in fish containing a benzylamine derivative and an antimicrobial substance BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1994-03-16 EP claimed
EP-0587135-A1 Enhanced chemotherapeutic compositions against microbial infections in fish contaning a benzylamine derivative and an antimicrobial substance BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1994-03-16 EP claimed
EP-0088943-B1 COMPOSITION FOR THE RESORPTION OF INJECTED ANTIBACTERIAL SUBSTANCES AND MIXTURES CONTAINING A BENZYL AMINE DERIVATIVE BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1986-08-13 EP claimed
EP-0088943-A2 Composition for the resorption of injected antibacterial substances and mixtures containing a benzyl amine derivative BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1983-09-21 EP claimed