⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19716039 | 1.00 | — | — | |
| SCHEMBL2888549 | 1.00 | — | — | |
| SCHEMBL8576503 | 1.00 | — | — | |
| SCHEMBL1752718 | 0.82 | — | — | |
| SCHEMBL15960839 | 0.82 | — | — | |
| SCHEMBL7810859 | 0.82 | — | — | |
| SCHEMBL21388498 | 0.75 | L3MBTL1 (0.42) | — | |
| SCHEMBL19716121 | 0.74 | — | — | |
| SCHEMBL8522492 | 0.74 | ATM (0.43) | — | |
| SCHEMBL19301763 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236937-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093849-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |
| EP-3020712-B1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | ARATANA THERAPEUTICS NV (BE) | 2018-07-04 | — | — | EP | disclosed |
| EP-3020712-A1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | Aratana Therapeutics NV (BE) | 2016-05-18 | — | — | EP | disclosed |
| EP-2776414-B1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | ARATANA THERAPEUTICS NV (BE) | 2016-03-16 | — | — | EP | disclosed |
| US-9040699-B2 | Method for preparing cyclopropane derivatives | ARATANA THERAPEUTICS NV (BE) | 2015-05-26 | — | — | US | disclosed |
| US-20150051394-A1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | ARATANA THERAPEUTICS NV (BE) | 2015-02-19 | — | — | US | disclosed |
| EP-2776414-A1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | Aratana Therapeutics NV (BE) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013068042-A1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | OKAPI SCIENCES NV (BE) | 2013-05-16 | — | — | WO | disclosed |
| EP-0649840-B1 | Bis(hydroxymethyl)cyclopropylmethyl pyrimidine derivatives, their preparation and their use as anti-viral agents | AJINOMOTO KK (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-5496824-A | ZOSTER VIRUS WITH PYRIMIDINEDIONE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0649840-A1 | Bis(hydroxymethyl)cyclopropylmethyl pyrimidine derivatives, their preparation and their use as anti-viral agents | Ajinomoto Co., Inc. (JP) | 1995-04-26 | — | — | EP | disclosed |