Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 19/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507049 | 0.86 | P2RY12 (0.70) | P2RY12 | |
| SCHEMBL7507064 | 0.86 | P2RY12 (0.70) | P2RY12 | |
| SCHEMBL5002653 | 0.85 | P2RY12 (0.55) | P2RY12CYP2C9 | |
| Bicarbonate SCHEMBL7509640 | 0.83 | P2RY12 (0.66) | P2RY12CYP2C9 | |
| Bicarbonate SCHEMBL7510618 | 0.83 | P2RY12 (0.65) | P2RY12 | |
| Bicarbonate SCHEMBL7507037 | 0.82 | P2RY12 (0.68) | P2RY12CYP2C9 | |
| Bicarbonate SCHEMBL7509661 | 0.81 | P2RY12 (0.95) | P2RY12CYP2C9 | |
| Bicarbonate SCHEMBL7511337 | 0.81 | P2RY12 (0.63) | P2RY12 | |
| Bicarbonate SCHEMBL7510959 | 0.80 | P2RY12 (0.73) | P2RY12 | |
| Carbamic Acid SCHEMBL7514943 | 0.80 | P2RY12 (0.64) | P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946561-B1 | TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |