Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | CCR3 | P51677 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511867 | 0.91 | DRD4 (0.48) | DRD4DRD2DRD3TSHRUSP2 | |
| SCHEMBL7506361 | 0.89 | DRD4 (0.48) | DRD4DRD2DRD3HRH1CCR3 | |
| SCHEMBL7507260 | 0.88 | CCR3 (0.54) | DRD4DRD2HRH1CCR3CCR1 | |
| SCHEMBL6212264 | 0.88 | DRD4 (0.49) | DRD4DRD2DRD3HRH1CCR3 | |
| SCHEMBL6213426 | 0.86 | DRD4 (0.44) | DRD4DRD2DRD3HRH1CCR3 | |
| SCHEMBL7506440 | 0.84 | DRD4 (0.54) | DRD4DRD2DRD3HRH1CCR3 | |
| SCHEMBL7509383 | 0.83 | DRD2 (0.45) | DRD4DRD2DRD3HRH1CCR3 | |
| SCHEMBL6213645 | 0.81 | ABCB1 (0.56) | DRD4DRD2HRH1CCR3CCR1 | |
| SCHEMBL6213685 | 0.80 | ABCB1 (0.57) | DRD4DRD2DRD3HRH1CCR3 | |
| SCHEMBL6211304 | 0.79 | CCR3 (0.44) | DRD4DRD2DRD3HRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263724-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062728-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |