Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.61 |
| ▸ | CTSL | P07711 | 8/20 | 0.60 |
| ▸ | CTSS | P25774 | 7/20 | 0.60 |
| ▸ | CTSB | P07858 | 3/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3592461 | 0.90 | CTSK (0.64) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL7512715 | 0.90 | CTSK (0.58) | CTSKCTSLCTSSCTSB | |
| SCHEMBL8406499 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL4622199 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL4621195 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL7514109 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL3577128 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL7525753 | 0.86 | CTSK (0.61) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL8404288 | 0.86 | CAPN1 (0.68) | CTSKCTSLCTSSCTSBCAPN1 | |
| SCHEMBL3591988 | 0.86 | CAPN1 (0.68) | CTSKCTSLCTSSCTSBCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |