Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.67 |
| ▸ | METAP1 | P53582 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CTSD | P07339 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7353656 | 0.99 | METAP2 (0.66) | METAP2METAP1KMT2AMEN1POLB | |
| SCHEMBL7388039 | 0.83 | METAP2 (0.56) | METAP2METAP1KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL7351493 | 0.82 | METAP2 (0.55) | METAP2METAP1KMT2AMEN1POLB | |
| SCHEMBL6476461 | 0.80 | METAP2 (0.68) | METAP2METAP1KMT2AMEN1HPGD | |
| SCHEMBL7351848 | 0.80 | METAP2 (0.69) | METAP2METAP1POLBSMN1; SMN2 | |
| SCHEMBL7351333 | 0.80 | METAP2 (0.69) | METAP2METAP1POLBCTSDALDH1A1 | |
| SCHEMBL7356888 | 0.80 | METAP2 (0.69) | METAP2METAP1KMT2AMEN1HPGD | |
| SCHEMBL7360432 | 0.79 | METAP2 (0.57) | METAP2METAP1KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL7359791 | 0.79 | METAP2 (0.67) | METAP2METAP1KMT2AMEN1HPGD | |
| Hydrochloric Acid SCHEMBL7353393 | 0.79 | METAP2 (0.67) | METAP2METAP1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |