SCHEMBL7514945

SCHEMBL7514945

NC(=O)c1ccccc1OCC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 18/20 0.70
KCNH2 Q12809 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL4778129 0.96 CCR5 (0.65) CCR5KCNH2
SCHEMBL4773891 0.85 CCR5 (0.83) CCR5KCNH2
SCHEMBL4777246 0.83 CCR5 (0.85) CCR5KCNH2
SCHEMBL4775171 0.83 CCR5 (1.00) CCR5KCNH2
SCHEMBL4773805 0.83 CCR5 (0.76) CCR5KCNH2
Trifluoroacetic Acid SCHEMBL4773770 0.82 CCR5 (0.75) CCR5KCNH2
Hydrochloric Acid SCHEMBL4771685 0.82 CCR5 (0.98) CCR5KCNH2
SCHEMBL4773720 0.81 CCR5 (0.75) CCR5KCNH2
SCHEMBL4768886 0.81 CCR5 (0.95) CCR5KCNH2
SCHEMBL4773820 0.81 CCR5 (0.77) CCR5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1220842-A1 CYCLIC AMINE COMPOUNDS AS CCR5 ANTAGONISTS Takeda Chemical Industries, Ltd. (JP) 2002-07-10 EP disclosed
WO-2001025200-A1 CYCLIC AMINE COMPOUNDS AS CCR5 ANTAGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-12 WO disclosed