Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509747 | 0.95 | MAPT (0.42) | ALDH1A1MAPTCHRM4SMN1; SMN2KDM4E | |
| SCHEMBL5114901 | 0.95 | ALDH1A1 (0.47) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL5814433 | 0.92 | CHRM4 (0.39) | ALDH1A1MAPTCHRM4CLK1CLK2 | |
| SCHEMBL5121690 | 0.90 | CHRM4 (0.41) | ALDH1A1MAPTCHRM4SMN1; SMN2CLK1 | |
| SCHEMBL5120075 | 0.90 | MAPT (0.45) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL5814772 | 0.88 | ADORA2A (0.48) | ALDH1A1CHRM4SMN1; SMN2POLBKDM4E | |
| SCHEMBL5813927 | 0.87 | MAPT (0.51) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL7622357 | 0.87 | ALDH1A1 (0.46) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL7516589 | 0.85 | ESR1 (0.42) | ALDH1A1MAPTCHRM4CLK1CLK2 | |
| SCHEMBL5121202 | 0.85 | MAPT (0.44) | ALDH1A1MAPTCHRM4SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |