Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | DUSP10 | Q9Y6W6 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513198 | 0.78 | KDM4E (0.59) | CCNA2CDK2HTTDUSP10KDM4E | |
| SCHEMBL7119967 | 0.78 | NPC1 (0.41) | CCNA2CDK2NPC1RAB9AHTT | |
| SCHEMBL7239285 | 0.76 | KDR (0.63) | KDR | |
| Hydrochloric Acid SCHEMBL7518134 | 0.75 | KDR (0.62) | KDR | |
| SCHEMBL7127977 | 0.74 | MAPK14 (0.39) | CCNA2CDK2NPC1RAB9AHTT | |
| SCHEMBL7517869 | 0.74 | KDM4E (0.67) | CCNA2CDK2ALPLHTTACHE | |
| SCHEMBL7510711 | 0.73 | KDR (0.55) | CCNA2CDK2AURKAKDR | |
| SCHEMBL7127974 | 0.73 | IGF1R (0.52) | CCNA2CDK2AURKAKDR | |
| Hydrochloric Acid SCHEMBL7512667 | 0.72 | KDR (0.54) | CCNA2CDK2TTKAURKAKDR | |
| SCHEMBL7510604 | 0.70 | KDR (0.52) | CCNA2CDK2TTKAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856001-B1 | PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-08-28 | — | — | EP | disclosed |
| EP-0856001-A1 | PYRIMIDINE DERIVATIVES AS 5HT 2C?-RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-08-05 | — | — | EP | disclosed |
| US-5753663-A | 5HT2C ANTAGONIST, USEFUL FOR TREATING ANXIETY, PAIN, OBSESSIVE COMPULSIVE DISORDER, ALCOHOLISM, DEPRESSION, MIGRAINE, SLEEP DISORDER, ANOREXIA NERVOSA AND PRIAPISM | SYNTEX (U.S.A.) INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997012880-A1 | PYRIMIDINE DERIVATIVES AS 5HT2C-RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 1997-04-10 | — | — | WO | disclosed |