Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152328 | 0.87 | HTR2A (0.43) | HTR2ASLC6A4KCNH2ALDH1A1MEN1 | |
| SCHEMBL7515248 | 0.79 | TBXA2R (0.47) | HTR2ASLC6A4KCNH2ALDH1A1MEN1 | |
| SCHEMBL6151967 | 0.79 | HTR2A (0.66) | HTR2ASLC6A4KCNH2ALDH1A1MEN1 | |
| SCHEMBL7454203 | 0.78 | HTR2A (0.50) | HTR2ASLC6A4KCNH2ALDH1A1MEN1 | |
| SCHEMBL6151964 | 0.78 | PDE7A (0.49) | HTR2ASLC6A4KCNH2ALDH1A1MEN1 | |
| SCHEMBL6151811 | 0.75 | MEN1 (0.55) | ALDH1A1MEN1KMT2AGAAPKM | |
| SCHEMBL5836477 | 0.74 | SLC6A4 (0.66) | HTR2ASLC6A4KCNH2ALDH1A1MEN1 | |
| SCHEMBL7457814 | 0.73 | SLC6A4 (0.42) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL13860469 | 0.73 | HSD17B10 (0.54) | HTR2ASLC6A4KCNH2ALDH1A1MEN1 | |
| SCHEMBL22069594 | 0.71 | HSPB1 (0.61) | ALDH1A1MEN1KMT2AGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220831-A1 | BIARYL ETHER DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS | Pfizer Products Inc. (US) | 2002-07-10 | — | — | EP | disclosed |
| WO-2001027068-A1 | BIARYL ETHER DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2001-04-19 | — | — | WO | disclosed |