Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7890147 | 0.88 | PIK3CA (0.39) | MTORPIK3CA | |
| SCHEMBL752556 | 0.85 | MTOR (0.72) | MTORPIK3CAADORA2AADORA3ADORA1 | |
| SCHEMBL753664 | 0.84 | MTOR (0.74) | MTORPIK3CAADORA2AADORA3TGFBR1 | |
| SCHEMBL11032319 | 0.84 | MTOR (0.58) | MTORPIK3CAADORA2AADORA3TGFBR1 | |
| SCHEMBL756037 | 0.84 | PIK3CA (0.46) | MTORPIK3CA | |
| SCHEMBL11028514 | 0.80 | PIK3CA (0.37) | MTORPIK3CA | |
| SCHEMBL11031679 | 0.79 | MTOR (0.49) | MTORPIK3CAADORA2AADORA3TGFBR1 | |
| SCHEMBL755161 | 0.77 | MTOR (0.71) | MTORPIK3CAADORA2AADORA1 | |
| SCHEMBL755430 | 0.76 | PIK3CA (0.41) | MTORPIK3CA | |
| SCHEMBL2788163 | 0.75 | MTOR (0.57) | MTORPIK3CAADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | claimed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |