Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | MTOR | P42345 | 8/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756037 | 0.88 | PIK3CA (0.46) | PIK3CAMTOR | |
| SCHEMBL751578 | 0.88 | MTOR (0.53) | PIK3CAMTOR | |
| SCHEMBL11028514 | 0.84 | PIK3CA (0.37) | PIK3CAMTOR | |
| SCHEMBL755430 | 0.80 | PIK3CA (0.41) | PIK3CAMTOR | |
| SCHEMBL2771543 | 0.75 | PIK3CA (0.69) | PIK3CAMTORSHMT2 | |
| SCHEMBL752556 | 0.72 | MTOR (0.72) | PIK3CAMTOR | |
| SCHEMBL749520 | 0.72 | PIK3CA (0.52) | PIK3CAMTORSHMT2 | |
| SCHEMBL765755 | 0.71 | PIK3CA (0.66) | PIK3CAMTOR | |
| SCHEMBL753664 | 0.71 | MTOR (0.74) | PIK3CAMTOR | |
| SCHEMBL11032319 | 0.71 | MTOR (0.58) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |