Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.58 |
| ▸ | PRKDC | P78527 | 14/20 | 0.58 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.47 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.47 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.44 |
| ▸ | ADK | P55263 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511894 | 0.88 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL6055347 | 0.87 | ABL1 (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL21806882 | 0.76 | PIK3CD (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL8326897 | 0.74 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL21806817 | 0.74 | PIK3CD (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL14743030 | 0.72 | SRC (0.41) | ABL1SRCHCKFYN | |
| SCHEMBL30387566 | 0.72 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL8327348 | 0.71 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7078911 | 0.69 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL6235341 | 0.67 | EGFR (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020016976-A1 | Engineered protein kinases which can utilize modified nucleotide triphosphate substrates | PRINCETON UNIVERSITY | 2002-02-07 | — | — | US | disclosed |
| EP-1017823-A2 | ENGINEERED PROTEIN KINASES WHICH CAN UTILIZE MODIFIED NUCLEOTIDE TRIPHOSPHATE SUBSTRATES | PRINCETON UNIVERSITY (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1998035048-A2 | ENGINEERED PROTEIN KINASES WHICH CAN UTILIZE MODIFIED NUCLEOTIDE TRIPHOSPHATE SUBSTRATES | PRINCETON UNIVERSITY (US) | 1998-08-13 | — | — | WO | disclosed |