Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.77 |
| ▸ | ABL1 | P00519 | 9/20 | 0.77 |
| ▸ | CDK1 | P06493 | 5/20 | 0.77 |
| ▸ | SRC | P12931 | 8/20 | 0.69 |
| ▸ | PRKCA | P17252 | 6/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.60 |
| ▸ | PRKDC | P78527 | 6/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.48 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686760 | 0.91 | EGFR (0.76) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6689658 | 0.87 | EGFR (0.70) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL8327348 | 0.75 | PIK3CD (0.67) | EGFRABL1CDK1SRCPIK3CD | |
| SCHEMBL8326897 | 0.75 | PIK3CD (1.00) | EGFRABL1SRCPIK3CDPIK3CA | |
| SCHEMBL6235344 | 0.75 | EGFR (0.55) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL8117270 | 0.73 | EGFR (0.60) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL30387566 | 0.73 | PIK3CD (1.00) | EGFRABL1SRCPIK3CDPIK3CA | |
| SCHEMBL18797649 | 0.72 | EGFR (0.59) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL9820109 | 0.71 | RPS6KA3 (0.66) | EGFRABL1CDK1GSK3BPDGFRB | |
| SCHEMBL21807006 | 0.70 | EGFR (0.56) | EGFRABL1CDK1SRCPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836613-B1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-0832092-B1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0836613-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-22 | — | — | EP | disclosed |
| EP-0832092-A1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0682519-A4 | ADENOSINE KINASE INHIBITORS. | GENSIA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996040706-A1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | GENSIA-SICOR (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996040707-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5506347-A | ADENOSINE KINASE INHIBITOR | GENSIA, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0682519-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994017803-A9 | ADENOSINE KINASE INHIBITORS | — | 1994-09-29 | — | — | WO | disclosed |
| WO-1994017803-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | disclosed |