Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7143019 | 0.97 | MAPT (0.35) | MAPTNISCHCYP2A6TSHRCYP1A2 | |
| SCHEMBL7151578 | 0.97 | MAPT (0.37) | MAPTNISCHCYP2A6TSHRCYP1A2 | |
| SCHEMBL7180192 | 0.95 | MAPT (0.36) | MAPTNISCHCYP2A6TSHRCYP1A2 | |
| SCHEMBL7177927 | 0.95 | MAPT (0.36) | MAPTNISCHCYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL28815114 | 0.76 | MAPT (0.38) | MAPTNISCHCYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL8077847 | 0.74 | MAPT (0.37) | MAPTNISCHCYP2A6TSHRCYP1A2 | |
| SCHEMBL3965887 | 0.73 | MAPT (0.39) | MAPTCYP2A6TSHRCYP1A2ALDH1A1 | |
| Bromide SCHEMBL28815167 | 0.72 | MAPT (0.38) | MAPTCYP2A6TSHRCYP1A2ALDH1A1 | |
| SCHEMBL5702791 | 0.72 | MAPT (0.38) | MAPTCYP2A6TSHRCYP1A2ALDH1A1 | |
| Iodide SCHEMBL28815180 | 0.72 | MAPT (0.38) | MAPTCYP2A6TSHRCYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020133034-A1 | Polyolefin production | RAZAVI ABBAS (BE) | 2002-09-19 | — | — | US | disclosed |
| US-20020120161-A1 | Polyolefin production | RAZAVI ABBAS (BE) | 2002-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020133034-A1 | Polyolefin production | SRRM2, CSE1L, CACNA1A | MAPT 4856/4885NISCH 3608/4885CYP2A6 3045/4885 |
| US-20020120161-A1 | Polyolefin production | SRRM2, CSE1L, CACNA1A | MAPT 4861/4885NISCH 3638/4885CYP2A6 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.