Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.65 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.59 |
| ▸ | GRB2 | P62993 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3510986 | 1.00 | PTPN1 (0.65) | PTPN1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL2310526 | 0.84 | SLC7A5 (0.83) | PTPN1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL5497934 | 0.84 | SLC7A5 (0.65) | PTPN1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL5497939 | 0.84 | SLC7A5 (0.65) | PTPN1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL13620420 | 0.83 | PTPN1 (0.61) | PTPN1SLC7A5PTGS1ALPIPKM | |
| D-Fluoromethyltyrosine F-18 SCHEMBL14346426 | 0.83 | ITGB3 (0.64) | PTPN1SLC7A5PTGS1ALPIPKM | |
| D-Fluoromethyltyrosine SCHEMBL14343162 | 0.83 | ITGB3 (0.64) | PTPN1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL14406929 | 0.83 | PTPN1 (0.61) | PTPN1SLC7A5PTGS1ALPIPKM | |
| D-Fluoromethyltyrosine F-18 SCHEMBL15944856 | 0.83 | ITGB3 (0.64) | PTPN1SLC7A5PTGS1ALPIPKM | |
| D-Fluoromethyltyrosine F-18 SCHEMBL14342997 | 0.83 | ITGB3 (0.64) | PTPN1SLC7A5PTGS1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2876165-A1 | Improved method for producing modifed target polypeptides | ACIB GmbH (AT) | 2015-05-27 | — | — | EP | claimed |
| US-20250242053-A1 | RECOMBINANT THERAPEUTIC FMR1 CONSTRUCTS AND METHODS OF TREATING FRAGILE X SYNDROME AND RELATED DISORDERS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2025-07-31 | — | — | US | disclosed |
| US-20250136651-A1 | RECOMBINANT OPTIMIZED MECP2 CASSETTES AND METHODS FOR TREATING RETT SYNDROME AND RELATED DISORDERS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2025-05-01 | — | — | US | disclosed |
| EP-4514980-A1 | RECOMBINANT THERAPEUTIC FMR1 CONSTRUCTS AND METHODS OF TREATING FRAGILE X SYNDROME AND RELATED DISORDERS | The University Court Of The University of Edinburgh (GB) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023114816-A9 | RECOMBINANT OPTIMIZED GALC CONSTRUCTS AND METHODS FOR TREATING GALC-ASSOCIATED DISORDERS | NEUROGENE INC. (US) | 2025-01-16 | — | — | WO | disclosed |
| CN-119301258-A | Recombinant therapeutic FMR1 constructs and methods of treating fragile X syndrome and related disorders | 爱丁堡大学董事会 | 2025-01-10 | — | — | CN | disclosed |
| EP-4473121-A1 | RECOMBINANT OPTIMIZED MECP2 CASSETTES AND METHODS FOR TREATING RETT SYNDROME AND RELATED DISORDERS | The University Court Of The University of Edinburgh (GB) | 2024-12-11 | — | — | EP | disclosed |
| CN-118696126-A | Recombinant optimized MECP2 cassettes and methods for treating Rate syndrome and related disorders | 爱丁堡大学董事会 | 2024-09-24 | — | — | CN | disclosed |
| WO-2023209364-A1 | RECOMBINANT THERAPEUTIC FMR1 CONSTRUCTS AND METHODS OF TREATING FRAGILE X SYNDROME AND RELATED DISORDERS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023144565-A1 | RECOMBINANT OPTIMIZED MECP2 CASSETTES AND METHODS FOR TREATING RETT SYNDROME AND RELATED DISORDERS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2023-08-03 | — | — | WO | disclosed |
| US-20140193880-A1 | MODIFIED FACTOR VIII AND FACTOR IX GENES AND VECTORS FOR GENE THERAPY | ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-8632765-B2 | Modified factor VIII and factor IX genes and vectors for gene therapy | Asklepios Biopharmaceuticals, Inc. (US) | 2014-01-21 | — | — | US | disclosed |
| WO-2013116244-A1 | PRODUCTION OF MUCONIC ACID FROM GENETICALLY ENGINEERED MICROORGANISMS | MYRIANT CORPORATION (US) | 2013-08-08 | — | — | WO | disclosed |
| US-20130004462-A1 | MODIFIED FACTOR VIII AND FACTOR IX GENES AND VECTORS FOR GENE THERAPY | AskBio Inc. | 2013-01-03 | — | — | US | disclosed |
| US-8198421-B2 | Modified factor VIII and factor IX genes and vectors for gene therapy | ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| WO-2012038444-A1 | LIPASE CONGENERS WITH ENHANCED SUBSTRATE ACCESS | Technische Universität Hamburg-Harburg (DE) | 2012-03-29 | — | — | WO | disclosed |
| EP-2431461-A1 | Lipase congeners with enhanced substrate access | Technische Universität Hamburg-Harburg (DE) | 2012-03-21 | — | — | EP | disclosed |
| US-20100284971-A1 | MODIFIED FACTOR VIII AND FACTOR IX GENES AND VECTORS FOR GENE THERAPY | ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| EP-2037892-A2 | MODIFIED FACTOR VIII AND FACTOR IX GENES AND VECTORS FOR GENE THERAPY | Asklepios Biopharmaceutical, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007149852-A2 | MODIFIED FACTOR VIII AND FACTOR IX GENES AND VECTORS FOR GENE THERAPY | ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) | 2007-12-27 | — | — | WO | disclosed |