Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518633 | 0.91 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11MAP2K2 | |
| SCHEMBL7513578 | 0.90 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11MAP2K2 | |
| SCHEMBL7514709 | 0.90 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11MAP2K2 | |
| SCHEMBL7510773 | 0.88 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MAP2K2 | |
| SCHEMBL7513452 | 0.86 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11MAP2K2 | |
| SCHEMBL5174459 | 0.82 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL7514387 | 0.82 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL1908412 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL7514848 | 0.80 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11MAP2K2 | |
| SCHEMBL7509072 | 0.79 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |