Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | PLG | P00747 | 3/20 | 0.42 |
| ▸ | PLAU | P00749 | 3/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506656 | 0.87 | F2 (0.43) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| SCHEMBL7511195 | 0.87 | F2 (0.47) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| SCHEMBL7506678 | 0.86 | F2 (0.43) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| SCHEMBL7511393 | 0.86 | F2 (0.42) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| Hydrochloric Acid SCHEMBL7508858 | 0.86 | F2 (0.46) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| SCHEMBL7512150 | 0.84 | F2 (0.42) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| SCHEMBL7510978 | 0.83 | OPRM1 (0.42) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| Fumaric Acid SCHEMBL7509172 | 0.83 | F2 (0.39) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| SCHEMBL7516653 | 0.82 | OPRM1 (0.43) | SMN1; SMN2ALDH1A1F2PLGPLAU | |
| SCHEMBL7518387 | 0.81 | F2 (0.40) | SMN1; SMN2ALDH1A1F2PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |