SCHEMBL7516259

SCHEMBL7516259

CCCCCc1ccc(C(=O)O)c(-c2ccc(C#N)cc2)c1F

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.46
HSD17B10 Q99714 1/20 0.46
RARB P10826 9/20 0.45
RARA P10276 3/20 0.45
RARG P13631 1/20 0.45
GRIA2 P42262 2/20 0.42
GRIA4 P48058 2/20 0.42
LTB4R2 Q9NPC1 1/20 0.39
PPARA Q07869 1/20 0.38
MGLL Q99685 1/20 0.37
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
MTOR P42345 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4651806 0.96 GRIA2 (0.43) TSHRHSD17B10RARBRARARARG
SCHEMBL7511313 0.91 GRIA2 (0.44) TSHRHSD17B10RARBRARARARG
SCHEMBL7511079 0.87 GRIA2 (0.47) GRIA2GRIA4LTB4R2
SCHEMBL8036180 0.85 RARB (0.43) TSHRHSD17B10RARBRARARARG
SCHEMBL8036061 0.84 RARB (0.47) RARBRARARARGGRIA2GRIA4
SCHEMBL8049053 0.81 GRIA2 (0.38) RARBRARAGRIA2GRIA4LTB4R2
SCHEMBL8048277 0.81 GRIA2 (0.38) GRIA2GRIA4LTB4R2
SCHEMBL8034244 0.81 GRIA2 (0.40) RARBRARAGRIA2GRIA4LTB4R2
SCHEMBL8678446 0.79 TSHR (0.46) TSHRHSD17B10RARBRARARARG
SCHEMBL11303166 0.77 GRIA4 (0.43) RARBRARARARGGRIA2GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0742275-B1 LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORP (JP) 2002-03-20 EP disclosed
EP-0805134-B1 NOVEL LIQUID-CRYSTAL COMPOUNDS BEARING DIENYL MOIETY AND LIQUID-CRYSTAL COMPOSITION CHISSO CORP (JP) 2000-08-30 EP disclosed
US-6086964-A Liquid crystalline compound having dienyl moiety and liquid crystal composition CHISSO CORPORATION (JP) 2000-07-11 US disclosed
EP-0733692-B1 Liquid crystalline compound, liquid crystal composition containing the same, and display device CHISSO CORP (JP) 2000-06-14 EP disclosed
US-6001275-A LIQUID CRYSTALLINE COMPOUND WHICH HAS A LARGE RATIO OF ELASTIC CONSTANTS, HAS A LOW VISCOSITY, EXCELLENT MISCIBILITY WITH OTHER LIQUID CRYSTALLINE COMPOUND, CHEMICALLY STABLE; HAVING AN UNCONJUGATED ALKADIENYL GROUP AT A SIDE CHAIN. CHISSO CORPORATION (JP) 1999-12-14 US disclosed
US-5833879-A LOW TEMPERATURE MISCIBILITY AND COMPATIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS; DISPLAYS CONTAINING MIXTURES OF AT LEAST TWO COMPOUNDS, PHYSICAL PROPERTIES CHISSO CORPORATION (JP) 1998-11-10 US disclosed
EP-0805134-A1 NOVEL LIQUID-CRYSTAL COMPOUNDS BEARING DIENYL MOIETY AND LIQUID-CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-11-05 EP disclosed
EP-0742275-A1 LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORPORATION (JP) 1996-11-13 EP disclosed