Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 4/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797815 | 0.79 | NPSR1 (0.48) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL7519181 | 0.78 | NPSR1 (0.37) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL14139877 | 0.77 | NPSR1 (0.46) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL14755445 | 0.77 | ALDH1A1 (0.46) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL14755456 | 0.75 | ALDH1A1 (0.44) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL2454517 | 0.75 | TAAR1 (0.50) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL7526681 | 0.74 | CA1 (0.33) | NPSR1KDM4EALDH1A1MAPTESR1 | |
| SCHEMBL15715987 | 0.73 | TYR (0.50) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL29713830 | 0.73 | ALDH1A1 (0.52) | NPSR1HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL224889 | 0.73 | ALDH1A1 (0.52) | NPSR1HPGDMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |