Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | PDE4A | P27815 | 5/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636037 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL302947 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29679711 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL753579 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL752748 | 0.90 | PDE4B (0.53) | CA1CA2ACHEPDE4APDE4B | |
| SCHEMBL15580915 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15869362 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15869339 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15580926 | 0.90 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18826576 | 0.87 | PDE4B (0.48) | CA1CA2ACHEPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107964016-B | Thiophene derivatives | 天津合美医药科技有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-108059635-B | Thiophene derivatives | 天津合美医药科技有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-107722036-B | Thiophene derivatives | 天津合美医药科技有限公司 | 2020-09-04 | — | — | CN | disclosed |
| US-10662189-B2 | PDE4 inhibitor | Shijiazhuang Sagacity New Drug Development Co., Ltd. (CN) | 2020-05-26 | — | — | US | disclosed |
| US-10611775-B2 | Thiophene derivatives | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2020-04-07 | — | — | US | disclosed |
| US-20190322684-A1 | THIOPHENE DERIVATIVES | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2019-10-24 | — | — | US | disclosed |
| US-10385062-B2 | Thiophene derivatives | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2019-08-20 | — | — | US | disclosed |
| EP-3502111-A1 | PDE4 INHIBITOR | Shijiazhuang Sagacity New Drug Development Co., Ltd. (CN) | 2019-06-26 | — | — | EP | disclosed |
| US-20190177318-A1 | PDE4 INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2019-06-13 | — | — | US | disclosed |
| US-20170197982-A1 | THIOPHENE DERIVATIVES | GANZHOU HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2017-07-13 | — | — | US | disclosed |
| US-9630975-B2 | Thiophene derivatives | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2017-04-25 | — | — | US | disclosed |
| US-8952178-B2 | Thiophene derivatives | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2015-02-10 | — | — | US | disclosed |
| US-20140255342-A1 | THIOPHENE DERIVATIVES | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-09-11 | — | — | US | disclosed |
| EP-2431371-B1 | THIOPHENE DERIVATIVES | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2013-10-09 | — | — | EP | disclosed |
| US-20120107269-A1 | THIOPHENE DERIVATIVES | Tianjin Hemay Biotech Co., Ltd (CN) | 2012-05-03 | — | — | US | disclosed |
| EP-2431371-A1 | THIOPHENE DERIVATIVES | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2012-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385062-B2 | Thiophene derivatives | TSHR, RB1, TAS2R7 | CA1 4732/4885CA2 4531/4885ACHE 273/4885 |
| US-20190177318-A1 | PDE4 INHIBITOR | PDE4A, PDE12, PDE4B | CA1 2356/4885CA2 601/4885ACHE 128/4885 |
| US-20120107269-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | CA1 4732/4885CA2 4531/4885ACHE 273/4885 |
| US-10611775-B2 | Thiophene derivatives | TSHR, RB1, TAS2R7 | CA1 4732/4885CA2 4531/4885ACHE 273/4885 |
| US-20170197982-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | CA1 4732/4885CA2 4531/4885ACHE 273/4885 |
| US-20140255342-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | CA1 4732/4885CA2 4531/4885ACHE 273/4885 |
| US-10662189-B2 | PDE4 inhibitor | PDE4A, PDE12, PDE4B | CA1 2356/4885CA2 601/4885ACHE 128/4885 |
| US-20190322684-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | CA1 4732/4885CA2 4531/4885ACHE 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.