Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.59 |
| ▸ | PDE4A | P27815 | 9/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636037 | 1.00 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL15580926 | 1.00 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL302947 | 1.00 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL15869339 | 1.00 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL15869362 | 1.00 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL15580915 | 1.00 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL29679711 | 1.00 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL752748 | 0.94 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL16572255 | 0.91 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL706429 | 0.91 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118047701-A | Preparation method of apremilast intermediate | 浙江华义制药有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-110627694-B | Method for recovering 3-ethoxy-4-methoxy-alpha- [ (methylsulfonyl) methyl ] -benzylamine | 山东邹平大展新材料有限公司 | 2021-06-15 | — | — | CN | claimed |
| CN-107860844-B | Method for detecting (S) -1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethylamine | 中山奕安泰医药科技有限公司 | 2020-07-07 | — | — | CN | claimed |
| CN-110627694-A | Method for recovering 3-ethoxy-4-methoxy-alpha- [ (methylsulfonyl) methyl ] -benzylamine | 山东邹平大展新材料有限公司 | 2019-12-31 | — | — | CN | claimed |
| US-20180334429-A1 | PROCESS FOR PREPARATION OF APREMILAST AND ITS INTERMEDIATES | Dr Reddys Laboratories Ltd (IN) | 2018-11-22 | — | — | US | claimed |
| EP-3619195-B1 | NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE | UNICHEM LAB LTD (IN) | 2025-07-23 | — | — | EP | disclosed |
| CN-119390623-A | Racemization preparation method of apremilast and intermediate thereof | 菏泽皓元医药科技有限公司 | 2025-02-07 | — | — | CN | disclosed |
| CN-118047701-A | Preparation method of apremilast intermediate | 浙江华义制药有限公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-118047701-A | Preparation method of apremilast intermediate | 浙江华义制药有限公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-107964016-B | Thiophene derivatives | 天津合美医药科技有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-108059635-B | Thiophene derivatives | 天津合美医药科技有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-110627694-B | Method for recovering 3-ethoxy-4-methoxy-alpha- [ (methylsulfonyl) methyl ] -benzylamine | 山东邹平大展新材料有限公司 | 2021-06-15 | — | — | CN | disclosed |
| WO-2013126495-A2 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | CELGENE CORPORATION (US) | 2013-08-29 | — | — | WO | disclosed |
| US-20130217919-A1 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | CELGENE CORPORATION (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217919-A1 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | CELGENE CORPORATION (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217919-A1 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | CELGENE CORPORATION (US) | 2013-08-22 | — | — | US | disclosed |
| US-8415485-B2 | Processes for the preparation of 2-(1-phenylethyl)isoindolin-1-one compounds | CELGENE CORPORATION (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120107269-A1 | THIOPHENE DERIVATIVES | Tianjin Hemay Biotech Co., Ltd (CN) | 2012-05-03 | — | — | US | disclosed |
| EP-2431371-A1 | THIOPHENE DERIVATIVES | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2012-03-21 | — | — | EP | disclosed |
| US-20110087033-A1 | Processes for the Preparation of 2-(1-Phenylethyl)isoindolin-1-one Compounds | AMGEN INC. | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110087033-A1 | Processes for the Preparation of 2-(1-Phenylethyl)isoindolin-1-one Compounds | PNMT, CYP2E1, CYP1A1 | PDE4B 2125/4885PDE4A 2697/4885PDE4C 2410/4885 |
| US-20180334429-A1 | PROCESS FOR PREPARATION OF APREMILAST AND ITS INTERMEDIATES | CMA1, MAST1, TPMT | PDE4B 241/4885PDE4A 406/4885PDE4C 1276/4885 |
| US-20120107269-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | PDE4B 1282/4885PDE4A 1596/4885PDE4C 1755/4885 |
| US-20130217919-A1 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | STS, SULT2A1, CBS | PDE4B 3924/4885PDE4A 4110/4885PDE4C 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.