Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 4/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7514046 | 0.87 | RXFP1 (0.53) | BCL6RXFP1DHFRKDRADORA3 | |
| SCHEMBL7519009 | 0.85 | RXFP1 (0.49) | BCL6RXFP1PLK4KDRNR1I2 | |
| SCHEMBL7515653 | 0.82 | RXFP1 (0.62) | BCL6RXFP1DHFREGFRTYMS | |
| SCHEMBL7514733 | 0.81 | RXFP1 (0.52) | BCL6RXFP1KDRADORA3SLC6A2 | |
| SCHEMBL7519775 | 0.78 | RXFP1 (0.62) | BCL6RXFP1DHFREGFRTYMS | |
| SCHEMBL7519748 | 0.78 | RXFP1 (0.54) | RXFP1KDM4EALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7521450 | 0.76 | RXFP1 (0.56) | BCL6RXFP1DHFREGFRTYMS | |
| SCHEMBL9145080 | 0.76 | RXFP1 (0.71) | RXFP1DHFREGFRTYMSKDM4E | |
| SCHEMBL19846671 | 0.76 | BCL6 (1.00) | BCL6EGFRROCK1ALDH1A1 | |
| SCHEMBL7513791 | 0.76 | ABCG2 (0.46) | RXFP1L3MBTL1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |