Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | BCL6 | P41182 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7514733 | 0.97 | RXFP1 (0.52) | RXFP1MAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL7516551 | 0.85 | BCL6 (0.61) | RXFP1ALDH1A1BCL6NR1I2AHR | |
| SCHEMBL5203892 | 0.79 | SCN9A (0.46) | MAPTALDH1A1GAAHSP90AA1BCL6 | |
| Hydrochloric Acid SCHEMBL7514046 | 0.79 | RXFP1 (0.53) | RXFP1MAPTALDH1A1GAABCL6 | |
| SCHEMBL7519748 | 0.76 | RXFP1 (0.54) | RXFP1MAPTALDH1A1MEN1RAB9A | |
| SCHEMBL7515653 | 0.72 | RXFP1 (0.62) | RXFP1MAPTALDH1A1BCL6MEN1 | |
| SCHEMBL7519775 | 0.71 | RXFP1 (0.62) | RXFP1MAPTALDH1A1GAABCL6 | |
| SCHEMBL7513830 | 0.71 | RXFP1 (0.49) | RXFP1MAPTALDH1A1MAPK8KDM4E | |
| SCHEMBL7513791 | 0.71 | ABCG2 (0.46) | RXFP1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL7519746 | 0.70 | RXFP1 (0.54) | RXFP1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |