Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Dimethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL1033026 | 0.98 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Dimethylamine SCHEMBL1491853 | 0.95 | HDAC3 (0.42) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Dimethylamine SCHEMBL2982085 | 0.95 | HDAC3 (0.42) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Dimethylamine SCHEMBL12393363 | 0.93 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Bromide SCHEMBL4851394 | 0.93 | — | — | |
| SCHEMBL17818 | 0.90 | — | — | |
| SCHEMBL10862599 | 0.88 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Hydrochloric Acid SCHEMBL2564981 | 0.87 | — | — | |
| Ethylene SCHEMBL5835732 | 0.87 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Ammonia Solution, Strong SCHEMBL534131 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525450-A | QUATERNARY AMMONIUM AND ACID GROUP CONTAINING POLYMER SEGMENTS IN NONPOLAR LIQUID | XEROX CORPORATION (US) | 1996-06-11 | — | — | US | claimed |
| EP-1193365-B1 | Reducing subterranean formation water permeability | HALLIBURTON ENERGY SERV INC (US) | 2014-12-03 | — | — | EP | disclosed |
| US-6476169-B1 | Methods of reducing subterranean formation water permeability | HALLIBURTON ENERGY SERVICES, INC. | 2002-11-05 | — | — | US | disclosed |
| EP-1193365-A1 | Reducing subterranean formation water permeability | Halliburton Energy Services, Inc. (US) | 2002-04-03 | — | — | EP | disclosed |