Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 12/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20909872 | 0.79 | PNMT (0.66) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL4564040 | 0.79 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CKDM4E | |
| SCHEMBL31336037 | 0.78 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL12280123 | 0.78 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL28154001 | 0.78 | PNMT (0.39) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL2514114 | 0.78 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL8648256 | 0.78 | PNMT (0.64) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL12280066 | 0.78 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL5678366 | 0.78 | PNMT (0.64) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL12168266 | 0.78 | PNMT (0.64) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |
| CN-1207098-A | Amidine and isothiourea derivatives as nitric oxide synthase inhibitors | ASTRA AB (SE) | 1999-02-03 | — | — | CN | disclosed |