SCHEMBL7517262

SCHEMBL7517262

COC=C1CCc2cc(OC)ccc2C1=O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 7/20 0.66
SMN1; SMN2 Q16637 5/20 0.63
ALDH1A1 P00352 4/20 0.63
MAPT P10636 4/20 0.63
CYP26A1 O43174 3/20 0.63
LMNA P02545 3/20 0.63
CYP19A1 P11511 1/20 0.63
MAPK1 P28482 1/20 0.61
NPC1 O15118 4/20 0.60
RAB9A P51151 4/20 0.60
KDM4E B2RXH2 3/20 0.60
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
HPGD P15428 2/20 0.60
ABCB1 P08183 2/20 0.60
CYP27A1 Q02318 2/20 0.60
NFKB1 P19838 1/20 0.60
NFKB2 Q00653 1/20 0.60
RELA Q04206 1/20 0.60
PKM P14618 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7510755 0.89 MAOB (0.67) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL12760787 0.84 MIF (0.67) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL6361514 0.84 MIF (0.67) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL7518085 0.83 MIF (0.47) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL29946409 0.82 MIF (0.63) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL7001016 0.82 MIF (0.63) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL7001015 0.82 MIF (0.63) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL6958968 0.82 MIF (0.85) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL30938680 0.82 MIF (0.63) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1
SCHEMBL14137061 0.81 MIF (0.65) MIFSMN1; SMN2ALDH1A1MAPTCYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0856001-B1 PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2002-08-28 EP disclosed
EP-0856001-A1 PYRIMIDINE DERIVATIVES AS 5HT 2C?-RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1998-08-05 EP disclosed
US-5753663-A 5HT2C ANTAGONIST, USEFUL FOR TREATING ANXIETY, PAIN, OBSESSIVE COMPULSIVE DISORDER, ALCOHOLISM, DEPRESSION, MIGRAINE, SLEEP DISORDER, ANOREXIA NERVOSA AND PRIAPISM SYNTEX (U.S.A.) INC. (US) 1998-05-19 US disclosed
WO-1997012880-A1 PYRIMIDINE DERIVATIVES AS 5HT2C-RECEPTOR ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 1997-04-10 WO disclosed