Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | HTR1B | P28222 | 8/20 | 0.44 |
| ▸ | HTR1D | P28221 | 8/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7514648 | 0.95 | HTR1A (0.53) | HTR1AHTR1BHTR1DDRD2 | |
| Malic Acid SCHEMBL10347626 | 0.90 | HTR1A (0.48) | HTR1AHTR1BHTR1DDRD2 | |
| SCHEMBL7509146 | 0.85 | HTR1A (0.67) | HTR1AHTR1BHTR1DDRD2 | |
| SCHEMBL7509059 | 0.85 | HTR1A (0.48) | HTR1AHTR1BHTR1DDRD2 | |
| Iodide SCHEMBL7510396 | 0.84 | HTR1A (0.65) | HTR1AHTR1BHTR1DDRD2 | |
| SCHEMBL6364891 | 0.83 | HTR1A (0.81) | HTR1AHTR1BHTR1DDRD2 | |
| SCHEMBL6765275 | 0.83 | HTR1A (0.81) | HTR1AHTR1BHTR1DDRD2 | |
| SCHEMBL8983347 | 0.83 | HTR1A (0.81) | HTR1AHTR1BHTR1DDRD2 | |
| Acetic Acid SCHEMBL7515123 | 0.82 | HTR1A (0.66) | HTR1AHTR1BHTR1DDRD2 | |
| Bromide SCHEMBL7511914 | 0.82 | HTR1A (0.80) | HTR1AHTR1BHTR1DDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0444852-B1 | Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole | LILLY CO ELI (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5397799-A | Anxiolytic agents, antidepressants | ELI LILLY AND COMPANY (US) | 1995-03-14 | — | — | US | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0444852-A2 | Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole | ELI LILLY AND COMPANY (US) | 1991-09-04 | — | — | EP | disclosed |