SCHEMBL7518372

SCHEMBL7518372

COc1cc(CCC[Si](C)(C)Cl)ccc1OC(C)=O

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.54
LTA4H P09960 2/20 0.51
TSHR P16473 1/20 0.47
TRPV1 Q8NER1 1/20 0.46
MTNR1A P48039 2/20 0.46
MTNR1B P49286 2/20 0.46
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45
ALDH1A1 P00352 2/20 0.44
NR3C1 P04150 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13133226 0.88 PTGS1 (0.56) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL13828939 0.87 PTGS1 (0.54) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL4603040 0.86 PTGS1 (0.57) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL29939055 0.86 PTGS1 (0.57) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL19229230 0.86 PTGS1 (0.53) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL31679626 0.85 PTGS1 (0.47) PTGS1CA12CA1CA2CA9
SCHEMBL15490483 0.85 PTGS1 (0.52) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL12364504 0.83 PTGS1 (0.50) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL12056129 0.82 LTA4H (0.49) PTGS1LTA4HTSHRTRPV1MTNR1A
SCHEMBL18230914 0.81 PTGS1 (0.48) PTGS1LTA4HTSHRTRPV1MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6492481-B1 THE SILICONE COPOLYCARBONATES CONTAIN RESIDUES OF SILICONE CONTAINING AND NONSILICONE CONTAINING BISPHENOLS AND HAVE PROPERTIES PARTICULARLY SUITED FOR USE IN HIGH DENSITY OPTICAL DATA STORAGE MEDIA. THE PROPERTIES OF SUBSTANTIALLY SINGLE GENERAL ELECTRIC COMPANY 2002-12-10 US disclosed
EP-1235872-A1 SUBSTANTIALLY SINGLE PHASE SILICONE COPOLYCARBONATES, METHODS, AND OPTICAL ARTICLES MADE THEREFROM GENERAL ELECTRIC COMPANY (US) 2002-09-04 EP disclosed
WO-2002004545-A1 SUBSTANTIALLY SINGLE PHASE SILICONE COPOLYCARBONATES, METHODS, AND OPTICAL ARTICLES MADE THEREFROM GENERAL ELECTRIC COMPANY (US) 2002-01-17 WO disclosed