Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 19/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 17/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 17/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 12/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6366688 | 0.92 | ADRA1A (0.84) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| Fumaric Acid SCHEMBL6366680 | 0.92 | ADRA1A (0.84) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| SCHEMBL6367117 | 0.81 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| SCHEMBL6315485 | 0.80 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| Hydrochloric Acid SCHEMBL9654113 | 0.80 | ADRA1A (0.69) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| SCHEMBL5612493 | 0.76 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| Fumaric Acid SCHEMBL6366889 | 0.74 | ADRA1A (0.84) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| Fumaric Acid SCHEMBL6366895 | 0.74 | ADRA1A (0.84) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| SCHEMBL6371025 | 0.73 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2CADRA2A | |
| SCHEMBL5612258 | 0.72 | ADRA1A (0.77) | ADRA1AADRA1DADRA1BADRA2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |