Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519746 | 0.90 | RXFP1 (0.54) | RXFP1MAPTSLC6A9SMN1; SMN2CYP3A4 | |
| SCHEMBL7510630 | 0.85 | RXFP1 (0.53) | RXFP1SLC6A9SMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL7513152 | 0.77 | RXFP1 (0.51) | RXFP1MAPTSLC6A9SMN1; SMN2CYP3A4 | |
| SCHEMBL7519304 | 0.71 | RXFP1 (0.42) | RXFP1CYP2D6CYP2C19 | |
| SCHEMBL7516527 | 0.67 | RXFP1 (0.52) | RXFP1SLC6A9SMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL7510615 | 0.66 | RXFP1 (0.59) | RXFP1MAPTSLC6A9CYP3A4CYP2D6 | |
| SCHEMBL7519748 | 0.64 | RXFP1 (0.54) | RXFP1MAPTSMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL7521450 | 0.64 | RXFP1 (0.56) | RXFP1MAPTSMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL7519009 | 0.63 | RXFP1 (0.49) | RXFP1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL7510610 | 0.61 | RXFP1 (0.59) | RXFP1MAPTSMN1; SMN2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |