Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 4/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3551443 | 0.90 | ALDH1A1 (0.57) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL3551445 | 0.90 | ALDH1A1 (0.57) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL8385634 | 0.89 | KCNH2 (0.56) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL7511355 | 0.88 | KCNH2 (0.65) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL7506628 | 0.87 | ALDH1A1 (0.53) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL2670591 | 0.86 | CYP3A4 (0.47) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL8385056 | 0.85 | KCNH2 (0.51) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL2670480 | 0.83 | KCNH2 (0.55) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL4750067 | 0.83 | KCNH2 (0.55) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL9779913 | 0.83 | KCNH2 (0.55) | KCNH2ALDH1A1POLBOPRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812838-B1 | PYRIDONECARBOXYLIC ACID DERIVATIVE SUBSTITUTED BY BICYCLIC AMINO GROUP, ESTER THEREOF, SALT THEREOF, AND BICYCLIC AMINE AS INTERMEDIATE THEREFOR | DAINIPPON PHARMACEUTICAL CO (JP) | 2002-05-02 | — | — | EP | disclosed |
| US-5990106-A | ANTIBIOTICS; 3-AZABICYCLO(3.2.0)HEPT-3-YL GROUP JOINED AT GIVEN POSITION OF A PYRIDONECARBOXYLIC ACID RESIDUE, SUCH AS 7-(1-AMINO-3-AZABICYCLO(3.2.0)HEPT-3-YL)-1-CYCLOPROPYL-6,8-DIFLUORO-1,4 -DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1999-11-23 | — | — | US | disclosed |
| EP-0812838-A1 | PYRIDONECARBOXYLIC ACID DERIVATIVE SUBSTITUTED BY BICYCLIC AMINO GROUP, ESTER THEREOF, SALT THEREOF, AND BICYCLIC AMINE AS INTERMEDIATE THEREFOR | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1997-12-17 | — | — | EP | disclosed |