Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013265 | 0.86 | CHRNB2 (0.54) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL8499061 | 0.86 | CHRNB2 (0.54) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL3013263 | 0.86 | CHRNB2 (0.54) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL13153487 | 0.82 | CHRNB2 (0.61) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL8827840 | 0.80 | CHRNB2 (0.54) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL4061110 | 0.77 | CHRNB2 (0.59) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL3017142 | 0.77 | CHRNB2 (0.59) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL3017144 | 0.77 | CHRNB2 (0.59) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL29511509 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL22714727 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171127-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATIVES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION | Targacept, Inc. (US) | 2002-01-16 | — | — | EP | claimed |
| WO-2000062767-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION | TARGACEPT, INC. (US) | 2000-10-26 | — | — | WO | claimed |