Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 1/20 | 0.43 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 10/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5124306 | 0.95 | USP1 (0.47) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL7505488 | 0.91 | USP1 (0.42) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL5128194 | 0.89 | CHRM4 (0.41) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL5130003 | 0.88 | USP1 (0.47) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL5814326 | 0.86 | PDE5A (0.47) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL5129031 | 0.86 | BCDIN3D (0.42) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL7510257 | 0.86 | PRKCI (0.39) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL5130866 | 0.85 | USP1 (0.46) | USP1WDR48MAPTNPSR1PDE5A | |
| SCHEMBL7516470 | 0.85 | PDE5A (0.39) | USP1WDR48MAPTPDE5AMEN1 | |
| SCHEMBL5816457 | 0.84 | NPC1 (0.43) | PDE5AMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |