Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | MERTK | Q12866 | 10/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 8/20 | 0.41 |
| ▸ | AXL | P30530 | 6/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520051 | 1.00 | ADORA2A (0.43) | ADORA2AADORA1ADORA3MERTKMAPK8 | |
| SCHEMBL7516597 | 0.90 | CHUK (0.39) | ADORA2AADORA1ADORA3MERTKMAPK8 | |
| SCHEMBL7511527 | 0.89 | RXFP1 (0.42) | ADORA2AADORA1MERTKMAPK8MAPK9 | |
| SCHEMBL7511522 | 0.89 | RXFP1 (0.42) | ADORA2AADORA1MERTKMAPK8MAPK9 | |
| SCHEMBL7510904 | 0.89 | RXFP1 (0.51) | ADORA1MERTKMAPK8MAPK9TYRO3 | |
| SCHEMBL7510908 | 0.89 | RXFP1 (0.51) | ADORA1MERTKMAPK8MAPK9TYRO3 | |
| SCHEMBL7516100 | 0.84 | MERTK (0.41) | MERTKMAPK8MAPK9TYRO3AXL | |
| SCHEMBL7513913 | 0.82 | RXFP1 (0.49) | MERTKMAPK8MAPK9TYRO3AXL | |
| SCHEMBL7513900 | 0.82 | RXFP1 (0.49) | MERTKMAPK8MAPK9TYRO3AXL | |
| SCHEMBL7513904 | 0.82 | RXFP1 (0.49) | MERTKMAPK8MAPK9TYRO3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |