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Hydrocortisone Acetate

Hydrocortisone Acetate

SCHEMBL7520412

CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 3/20 0.85
▸ HIF1A Q16665 11/20 0.93
▸ PGR P06401 4/20 0.93
▸ AR P10275 3/20 0.93
▸ SERPINA6 P08185 2/20 0.93
▸ LMNA P02545 2/20 0.93
▸ CHRM1 P11229 2/20 0.93
▸ SMN1; SMN2 Q16637 3/20 0.85
▸ KMT2A Q03164 3/20 0.85
▸ NR3C2 P08235 3/20 0.85
▸ CYP2C19 P33261 2/20 0.85
▸ HSD17B10 Q99714 2/20 0.85
▸ CYP3A4 P08684 2/20 0.85
▸ NFKB1 P19838 2/20 0.85
▸ MAPT P10636 2/20 0.85
▸ SHBG P04278 1/20 0.85
▸ TSHR P16473 2/20 0.73
▸ PMP22 Q01453 1/20 0.73
▸ POLB P06746 1/20 0.72
▸ GAA P10253 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrocortisone Acetate SCHEMBL365254 1.00 HIF1A (0.93) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL2679809 0.97 HIF1A (1.00) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL7419 0.97 HIF1A (1.00) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL2452043 0.97 HIF1A (1.00) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL25599370 0.97 HIF1A (1.00) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL4940901 0.97 HIF1A (1.00) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL13026148 0.97 HIF1A (1.00) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL2832039 0.96 HIF1A (0.98) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL11238411 0.96 HIF1A (0.98) HIF1APGRARSERPINA6LMNA
Hydrocortisone Acetate SCHEMBL11238414 0.96 HIF1A (0.98) HIF1APGRARSERPINA6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3458019-A1 PRODUCT FOR THE THERAPY AND PREVENTION OF BURNOUT SYNDROME OF THE SCALP AND THE SKIN Apomedica SAGL (CH) 2019-03-27 — — EP claimed
US-20150299366-A1 MOLECULARLY IMPRINTED POLYMER NANOPARTICLES COMPATIBLE WITH BIOLOGICAL SAMPLES AND PREPARATION METHOD THEREOF NANKAI UNIVERSITY (CN) 2015-10-22 — — US claimed
CN-116761893-A Method for transducing immune cells 艾洛基治疗公司 2023-09-15 — — CN disclosed
US-10053531-B2 Molecularly imprinted polymer nanoparticles compatible with biological samples and preparation method thereof NANKAI UNIVERSITY (CN) 2018-08-21 — — US disclosed
US-20180028516-A1 METHODS AND DEVICES FOR THE TREATMENT OF OCULAR DISEASES IN HUMAN SUBJECTS CLEARSIDE BIOMEDICAL, INC. 2018-02-01 — — US disclosed
US-20150299366-A1 MOLECULARLY IMPRINTED POLYMER NANOPARTICLES COMPATIBLE WITH BIOLOGICAL SAMPLES AND PREPARATION METHOD THEREOF NANKAI UNIVERSITY (CN) 2015-10-22 — — US disclosed
CN-1250562-C Process for preparing hydrocortisone acetate SHANDONG XINHUA PHARMACEUTICAL (CN) 2006-04-12 — — CN disclosed
CN-1603333-A Process for preparing hydrocortisone acetate SHANDONG XINHUA PHARMACEUTICAL (CN) 2005-04-06 — — CN disclosed
WO-2001010907-A9 THERAPEUTIC POLYPEPTIDES AND METHODS FOR USING SAME UNIV MARYLAND BIOTECH INST (US) 2002-07-11 — — WO disclosed