Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 5/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.98 |
| ▸ | PGR | P06401 | 4/20 | 0.98 |
| ▸ | AR | P10275 | 3/20 | 0.98 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | SHBG | P04278 | 1/20 | 0.77 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Acetate SCHEMBL2679809 | 0.99 | HIF1A (1.00) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL7419 | 0.99 | HIF1A (1.00) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL25599370 | 0.99 | HIF1A (1.00) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL4940901 | 0.99 | HIF1A (1.00) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL2452043 | 0.99 | HIF1A (1.00) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL13026148 | 0.99 | HIF1A (1.00) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL11238411 | 0.98 | HIF1A (0.98) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL11238414 | 0.98 | HIF1A (0.98) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL365254 | 0.96 | HIF1A (0.93) | HIF1APGRARSERPINA6LMNA | |
| Hydrocortisone Acetate SCHEMBL7520412 | 0.96 | HIF1A (0.93) | HIF1APGRARSERPINA6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242134-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2012-08-14 | — | — | US | disclosed |
| US-20100076016-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076016-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | KCNQ3, KCNK3, GRIK3 | NR3C1 492/4885HIF1A 4027/4885PGR 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.