Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526726 | 0.91 | HTT (0.49) | HTTPTPN1POLBKDM4EHSD17B10 | |
| SCHEMBL7519795 | 0.81 | HTT (0.49) | HTTPTPN1POLBKDM4EHSD17B10 | |
| SCHEMBL7527921 | 0.80 | KDM4E (0.34) | HTTPOLBKDM4EHSD17B10MAPT | |
| SCHEMBL2910532 | 0.72 | POLB (0.62) | HTTPTPN1POLBKDM4EHSD17B10 | |
| SCHEMBL18066346 | 0.69 | PTPN1 (0.73) | HTTPTPN1MAPTALDH1A1HPGD | |
| SCHEMBL16666424 | 0.69 | POLB (0.58) | HTTPTPN1POLBKDM4EHSD17B10 | |
| SCHEMBL7518269 | 0.69 | MAPT (0.34) | HTTPOLBKDM4EHSD17B10MAPT | |
| SCHEMBL15642113 | 0.67 | POLB (0.65) | HTTPTPN1POLBKDM4EHSD17B10 | |
| SCHEMBL7522909 | 0.67 | HTT (0.39) | HTTPTPN1POLBKDM4EHSD17B10 | |
| SCHEMBL8839500 | 0.67 | BACE1 (0.41) | HTTPOLBKDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |