Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TOP1 | P11387 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519795 | 0.85 | HTT (0.49) | HTTPOLBMAPTKDM4EHSD17B10 | |
| SCHEMBL8839500 | 0.83 | BACE1 (0.41) | HTTPOLBMAPTKDM4EHSD17B10 | |
| SCHEMBL7527848 | 0.81 | ALOX5 (0.37) | GAAMEN1KMT2AL3MBTL1 | |
| SCHEMBL7520303 | 0.78 | VCAM1 (0.33) | POLBMAPTGAATOP1ALDH1A1 | |
| SCHEMBL7520623 | 0.78 | TSHR (0.31) | TSHRSMN1; SMN2 | |
| SCHEMBL7526726 | 0.75 | HTT (0.49) | HTTPOLBMAPTKDM4EHSD17B10 | |
| SCHEMBL2910532 | 0.69 | POLB (0.62) | HTTPOLBMAPTKDM4EHSD17B10 | |
| SCHEMBL7096822 | 0.68 | HTT (0.45) | HTTPOLBMAPTKDM4EHSD17B10 | |
| SCHEMBL7705104 | 0.68 | ALDH1A1 (0.45) | HTTPOLBMAPTKDM4EHSD17B10 | |
| SCHEMBL7516554 | 0.68 | GAA (0.34) | MAPTGAATOP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |