Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.51 |
| ▸ | HPGD | P15428 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | DPYD | Q12882 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26780555 | 0.78 | PDE3B (0.53) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL26784496 | 0.77 | KDM4E (0.56) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL9341336 | 0.77 | KDM4E (0.49) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL10853063 | 0.76 | PDE3B (0.51) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL11018929 | 0.76 | PDE3B (0.54) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL11025183 | 0.75 | PDE3B (0.50) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL11025198 | 0.75 | PDE3B (0.50) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL214847 | 0.74 | KDM4E (0.57) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL10854285 | 0.74 | PDE3A (0.55) | PDE3BPDE3AKDM4EHPGDALDH1A1 | |
| SCHEMBL11021105 | 0.74 | PDE3B (0.49) | PDE3BPDE3AKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994173-B2 | 2-piperazin-1-yl-3H-imidazo[4,5-b]pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-09 | — | — | US | disclosed |
| US-7994173-B2 | 2-piperazin-1-yl-3H-imidazo[4,5-b]pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-09 | — | — | US | disclosed |
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-07 | — | — | US | disclosed |
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-07 | — | — | US | disclosed |
| EP-0945434-B1 | PROCESS FOR PRODUCING HALOGENATED HETEROARYL COMPOUNDS | BANYU PHARMA CO LTD (JP) | 2002-02-27 | — | — | EP | disclosed |
| US-6114524-A | REACTING A HYDROXY SUBSTITUTED-6-MEMBERED HETEROCYCLIC RING CONTAINING 1 OR 2 OR 3 NITROGEN ATOMS IN THE RING WITH TETRAALKYLAMMONIUM HALIDE IN PRESENCE OF PHOSPHORUS PENTAOXIDE IN MILD CONDITIONS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-09-05 | — | — | US | disclosed |
| EP-0945434-A1 | PROCESS FOR PRODUCING HALOGENATED HETEROARYL COMPOUNDS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | PDE3A, PDE3B, PTGIS | PDE3B 2/4885PDE3A 1/4885KDM4E 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.