Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.35 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.32 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874924 | 0.89 | SLC1A5 (0.38) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL4610837 | 0.88 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL3457996 | 0.88 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL3335322 | 0.88 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL27926628 | 0.86 | SLC7A5 (0.36) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL27615468 | 0.85 | SLC7A5 (0.41) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL7950365 | 0.85 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL3050307 | 0.85 | SLC7A5 (0.49) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL3050310 | 0.85 | SLC7A5 (0.49) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 | |
| Histidine SCHEMBL28093403 | 0.85 | SLC7A5 (0.45) | SLC7A5CYP3A4CYP1A2GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020155450-A1 | Genetic polymorphisms which are associated with autism spectrum Disorders | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2002-10-24 | — | — | US | disclosed |
| US-6228582-B1 | SCREENING FOR BRAIN DISORDERS; ISOLATE MAMMALIAN TISSUE SAMPLE, TEST SAMPLE FOR PREFERENTIAL POLYMORPHISM IN NUCLEOTIDE SEQUENCES | UNIVERSITY OF ROCHESTER | 2001-05-08 | — | — | US | disclosed |
| WO-1998058082-A1 | GENETIC POLYMORPHISMS WHICH ARE ASSOCIATED WITH AUTISM SPECTRUM DISORDERS | UNIVERSITY OF ROCHESTER (US) | 1998-12-23 | — | — | WO | disclosed |