Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 7/20 | 0.44 |
| ▸ | PDE5A | O76074 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5122520 | 0.94 | KDM4E (0.58) | KDM4EMAPK1PRKCIPDE5ANPC1 | |
| SCHEMBL7507758 | 0.91 | GBA1 (0.55) | MAPK1PDE5ANPC1MAPTRAB9A | |
| SCHEMBL7512034 | 0.87 | METAP1 (0.53) | KDM4EMAPK1PDE5ANPC1MAPT | |
| SCHEMBL7514681 | 0.86 | ADORA2A (0.43) | KDM4EMAPK1PDE5ANPC1MAPT | |
| SCHEMBL7505604 | 0.85 | NPC1 (0.40) | KDM4EMAPK1PDE5ANPC1MAPT | |
| SCHEMBL7516851 | 0.85 | PRKCI (0.41) | KDM4EMAPK1PRKCIPDE5AMAPT | |
| SCHEMBL5119410 | 0.85 | PDE5A (0.57) | KDM4EMAPK1PRKCIPDE5AMAPT | |
| SCHEMBL5125302 | 0.84 | GBA1 (0.60) | MAPK1PDE5ANPC1MAPTRAB9A | |
| SCHEMBL7513372 | 0.84 | PDE5A (0.55) | PRKCIPDE5AMAPTPTGS1TBXAS1 | |
| SCHEMBL8185712 | 0.83 | PDE5A (0.47) | KDM4EMAPK1PDE5ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |