Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128123 | 0.95 | PDE5A (0.60) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5128315 | 0.88 | PDE5A (0.59) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5815431 | 0.87 | PTGS2 (0.43) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5119410 | 0.85 | PDE5A (0.57) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5126440 | 0.85 | PDE5A (0.62) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5129296 | 0.85 | PDE5A (0.59) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL7521883 | 0.84 | KDM4E (0.53) | PDE5AMEN1KMT2AMAPTATM | |
| SCHEMBL5122225 | 0.84 | PRKCI (0.42) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL8185259 | 0.83 | PDE5A (0.60) | PDE5AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5129048 | 0.83 | PRKCI (0.58) | PDE5AMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |