Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14611861 | 1.00 | TDP1 (0.71) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL11451952 | 0.83 | TDP1 (1.00) | TDP1RAB9ANPC1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11451936 | 0.82 | TDP1 (0.96) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL25415051 | 0.80 | TDP1 (0.67) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL19380825 | 0.80 | TDP1 (0.67) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL22406435 | 0.80 | TDP1 (0.67) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL18803863 | 0.77 | TDP1 (0.62) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL7523674 | 0.76 | TDP1 (0.51) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL7517901 | 0.76 | TDP1 (0.51) | TDP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL7520091 | 0.76 | TDP1 (0.51) | TDP1RAB9ANPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937044-B1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NAT RECH SCIENT (FR) | 2002-01-30 | — | — | EP | disclosed |
| EP-0937044-A1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998005642-A1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-02-12 | — | — | WO | disclosed |