Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517901 | 0.83 | TDP1 (0.51) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL7525729 | 0.82 | TDP1 (0.47) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL7521932 | 0.76 | TDP1 (0.71) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL14611861 | 0.76 | TDP1 (0.71) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL7519789 | 0.74 | TDP1 (0.46) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL7518895 | 0.74 | TDP1 (0.46) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL10707006 | 0.73 | KDM4E (0.58) | RAB9AKMT2AMEN1NPC1ATM | |
| SCHEMBL25415051 | 0.73 | TDP1 (0.67) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL21742339 | 0.71 | TDP1 (0.59) | TDP1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL21742340 | 0.71 | TDP1 (0.59) | TDP1RAB9AKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937044-B1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NAT RECH SCIENT (FR) | 2002-01-30 | — | — | EP | disclosed |