Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 12/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597071 | 0.95 | MTNR1A (0.59) | MTNR1AHTR1ASLC6A4CXCR2ADRA1A | |
| SCHEMBL962394 | 0.90 | MTNR1A (0.58) | MTNR1AHTR1ASLC6A4CXCR2ADRA1A | |
| SCHEMBL7531535 | 0.84 | MTNR1A (0.60) | MTNR1AHTR1ASLC6A4CXCR2CTNNB1 | |
| SCHEMBL8584312 | 0.84 | MTNR1A (0.60) | MTNR1AHTR1ASLC6A4CXCR2ADRA1A | |
| SCHEMBL5871763 | 0.83 | MTNR1A (0.46) | MTNR1AHTR1ASLC6A4ADRA1A | |
| SCHEMBL6173819 | 0.83 | MTNR1A (0.59) | MTNR1AHTR1ASLC6A4CXCR2CTNNB1 | |
| SCHEMBL13534264 | 0.83 | MTNR1A (0.64) | MTNR1AHTR1ASLC6A4CTNNB1WNT3A | |
| SCHEMBL13202088 | 0.81 | MTNR1A (0.65) | MTNR1AHTR1ASLC6A4CXCR2CTNNB1 | |
| SCHEMBL8667866 | 0.81 | MTNR1A (0.58) | MTNR1AHTR1ASLC6A4CXCR2ADRA1A | |
| SCHEMBL7481895 | 0.81 | MTNR1A (0.58) | MTNR1AHTR1ASLC6A4CXCR2CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |