Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 14/20 | 0.65 |
| ▸ | ANPEP | P15144 | 1/20 | 0.64 |
| ▸ | CASP1 | P29466 | 5/20 | 0.53 |
| ▸ | CASP3 | P42574 | 4/20 | 0.51 |
| ▸ | CASP7 | P55210 | 4/20 | 0.51 |
| ▸ | CASP6 | P55212 | 3/20 | 0.51 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.51 |
| ▸ | CAPNS1 | P04632 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520605 | 1.00 | CAPN1 (0.65) | CAPN1ANPEPCASP1CASP3CASP7 | |
| SCHEMBL7512325 | 0.88 | ANPEP (0.60) | CAPN1ANPEPCASP1CASP3CASP7 | |
| SCHEMBL7513408 | 0.86 | ANPEP (0.58) | CAPN1ANPEPCASP1CASP3CASP7 | |
| SCHEMBL8808063 | 0.85 | CASP1 (0.72) | CAPN1CASP1CASP3CASP7CASP6 | |
| SCHEMBL8808053 | 0.85 | CASP1 (0.72) | CAPN1CASP1CASP3CASP7CASP6 | |
| SCHEMBL8812444 | 0.84 | CASP1 (0.73) | CAPN1CASP1CASP3CASP7CASP6 | |
| SCHEMBL8812448 | 0.84 | CASP1 (0.73) | CAPN1CASP1CASP3CASP7CASP6 | |
| SCHEMBL6770677 | 0.82 | CAPN1 (0.75) | CAPN1CASP3CAPNS1 | |
| SCHEMBL7515616 | 0.81 | ANPEP (0.64) | ANPEPCASP1CASP3CASP7CASP6 | |
| SCHEMBL8807569 | 0.80 | CAPN1 (0.55) | CAPN1CASP1CASP3CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |