Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | PRKCI | P41743 | 11/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781850 | 0.94 | MEN1 (0.57) | MEN1KMT2APDE5APRKCIMAPT | |
| SCHEMBL5780203 | 0.89 | PDE5A (0.62) | MEN1KMT2APDE5APRKCIMAPT | |
| SCHEMBL5816868 | 0.86 | MEN1 (0.49) | MEN1KMT2APDE5APRKCIMAPT | |
| SCHEMBL5779654 | 0.85 | MEN1 (0.54) | MEN1KMT2APDE5APRKCIMAPT | |
| SCHEMBL7617660 | 0.84 | RAB9A (0.51) | MEN1KMT2APRKCIMAPTSMN1; SMN2 | |
| SCHEMBL7170675 | 0.83 | KDM4E (0.56) | PRKCIMAPTHTTSMN1; SMN2PTGS2 | |
| SCHEMBL5781203 | 0.82 | PRKCI (0.55) | MEN1KMT2APDE5APRKCIMAPT | |
| SCHEMBL7168076 | 0.82 | MAPT (0.56) | MEN1KMT2APDE5APRKCIMAPT | |
| SCHEMBL5778488 | 0.81 | MEN1 (0.51) | MEN1KMT2APDE5APRKCIMAPT | |
| SCHEMBL7410138 | 0.80 | MEN1 (0.54) | MEN1KMT2APDE5APRKCIMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |